Biomarkers & ASD
A half-day symposium providing insight into research and current trials that point to the potential benefit of medical treatments to address environmentally-triggered impairments associated with autism spectrum disorders.
Recorded June 1, 2013 at UC Davis MIND Institute Auditorium in Sacramento, California. Videos are courtesy of Autism Research Institute, UC Davis MIND Institute & Autism Speaks.
Is There a Connection Between the Immune System and Autism?
The ideal immune system will:
- Recognize all foreign organisms (bacteria, viruses, parasites, fungi, worms).
- Efficiently and rapidly destroy invaders.
- Prevent a second infection with the same microbe (have a good memory).
- Never cause damage to self.
Things that can go wrong:
- Immune deficiency/dysfunction: defective or ineffective response.
- Hypersensitivity: Over-reaction to innocuous foreign material, out of proportion to potential damage (allergy).
- Autoimmunity: Inappropriate reaction towards self, loss of self-recognition.
- Inflammation: Too-vigorous attack against invaders with “bystander” damage to normal tissue.
Dysregulation of immunity in people with autism can lead to any of these four problems.
There is a tendency towards a positive family history of autoimmunity in families – Rheumatoid Arthritis, Thyroiditis – with an ASD child. Many, many types of autoantibodies (against “self” tissues) have been found in ASD children but the significance of the many types of anti-brain antibodies is not yet clear. Several studies find that some ASD children have low immunoglobulins (IgG, IgM, IgA), and/or low T cell numbers, altered cytokine profiles, and/or low-normal functioning and/or low NK cells; a subset of children have true immunodeficiency. Some children have low serum IgA, predisposing them to respiratory and GI infections.
Antibodies are divided up into classes:
- IgA: Mucosal surfaces – if this is low, it predisposes to respiratory and GI infections as well as autoimmunity; it is sometimes low in ASD children
- IgM: Rapid response bloodstream antibody made at the beginning of an infection; can be high or low in ASD
- IgG: Slower but longer lasting bloodstream antibody; can be high or low in ASD
- IgE: Allergy; can be high or normal in ASD
Conclusion #1: A child on the autism spectrum with recurrent infections deserves an immune evaluation for immunodeficiency.
Conclusion #2: A child on the autism spectrum with eczema, chronic nasal symptoms, asthma, significant GI symptoms, or recurrent respiratory infections deserves an allergy evaluation for IgE inhalant and food allergies.
A few studies published on the immune system and autism:
No continuing education credits are offered but free certificates of participation are available upon completion of a brief knowledge quiz at: https://www.classmarker.com/online-test/start/?quiz=gm45a82012072ae7 Published: 02/14/2018 Nancy O’Hara, M.D. is a board-certified pediatrician.
Judy Van de Water, Ph.D. describes gestational influences on neurodevelopment. Dr. Van de Water joined the faculty in the Department of Internal Medicine at the
Handouts are online at: http://www.ariconference.com/webinars/margolis.pdf Free certificates of participation are available online following successful completion of a brief knowledge quiz at: https://www.classmarker.com/online-test/login/ Kara Gross Margolis is a pediatric gastroenterologist whose clinical subspecialty
Certificates of participation are available upon completion of a brief knowledge quiz available online at: http://www.classmarker.com/online-test/start/?quiz=6ma535fea63d9e38 Autism is characterized by impairment of social cognition and repetitive behaviors, as well as language impairment. Evidence
Free certificates of participation are available upon successful completion of a learning quiz at: http://www.classmarker.com/online-test/start/?quiz=t665357ea6247811 Published: 04/23/2014 Length: 00:51:05 Dr. Fasano completed his medical training at the University of Naples in Italy,
According to the ARI Parent Survey, making dietary changes offer the most consistent benefit to people on the autistic spectrum. Come and learn why. Food is actually information, sending healing or hurting messages