ARI partially funded research leading up to a new study that gut microbiota is sufficient to promote autism-like behaviors in mice.
June 11, 2019 — In a study published earlier this month in Cell, researchers at Cal Tech used “germ-free” mice—laboratory animals that are grown in a microorganism-free environment— to examine the microbiota’s potential role in autism-like behavior in mice.
Fecal transplantation of gut microorganisms from children with autism were transferred into the “germ-free” mice while samples from people without autism were transplanted into other of animals. Following the transfer, investigators reported observing autism-like behaviors in the mice with microbiota from individuals diagnosed with ASD. Autism-like behaviors were not observed in mice that received fecal transplantation of microbiota from typically-developing individuals.
The behaviors characterized as “atuism-like” included fewer volcalizations, less social interaction with other mice, and repetitive behaviors. The investigators proposed that these symptoms are analogous behavioral symptoms frequently observed in people diagnosed with autism spectrum disorders.
Altered gene expression in their brains and differences in metabolic markers were also observed in mice that received human ASD microbiota.
Many studies have reported abnormal gut microbiota in individuals with Autism Spectrum Disorders (ASD), suggesting a link between gut microbiome and autism-like behaviors. Modifying the gut microbiome is